Planet (372) (1893 AH)

Dev120154 367..372

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extend...

366 - 372 Fung SY.pmd

The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated...

Bez nazwy-372

367-372 Kramer.p65

The world’s marine resources have long been viewed as inexhaustible supplies of protein and other products for the human population. However, as the adverse effects of human activity on marine and coastal ecosystems have become better understood, views of the sustainability of resource use have changed. Globally, there are increasing concerns about the sustainability of marine and coastal fishe...

Dmd049312 372..378

From a search of the available literature, a database of 22 drugs of all charge types and several different therapeutic classes was compiled to compare rat and human biliary clearance data. Dog biliary excretion data were also found for nine of the drugs. For 19 of the 22 drugs (86%), rat unbound biliary clearance values, when normalized for body weight, exceeded those for humans by factors ran...